Talk:Histocompatibility

Medicine Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.

Molecular Biology: MCB

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Mid-importance).

Wiki Education Foundation-supported course assignment[edit]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle65.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:23, 17 January 2022 (UTC)[reply]

Untitled[edit]

Seems like the Testing section would be benefitted by some paragraph breaks -Immcarle65 (talk) 02:03, 8 January 2018 (UTC)[reply]

Why are the tissues with same MHC genes compatible? doesn't organism exibit all of its self-peptides through MHC? it should require total compatibility, not only MHC genes, which are a few proteins. — Preceding unsigned comment added by 109.121.83.245 (talk) 22:10, 22 August 2012 (UTC)[reply]

Wiki Education Foundation-supported course assignment[edit]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle15. Peer reviewers: Immacarle14.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 23:30, 16 January 2022 (UTC)[reply]

Sources on Histocompatibility[edit]

Hello, I am a current student at Carleton College and I will be adding some information to this webpage from these sources:

Dreyer, G.j., A.c. Hemke, M.e.j. Reinders, and J.w. De Fijter. "Transplanting the Elderly: Balancing Aging with Histocompatibility." Transplantation Reviews 29.4 (2015): 205-11. Web.Cite error: There are <ref> tags on this page without content in them (see the help page).

Leffell, Mary S. "Histocompatibility Testing after Fifty Years of Transplantation." Manual of Molecular and Clinical Laboratory Immunology, 7th Edition 369.1-2 (2011): 1195-197. Web. Cite error: There are <ref> tags on this page without content in them (see the help page).

"Transplant Pathology Internet Services." Transplant Pathology Internet Services. Accessed February 03, 2016. http://tpis.upmc.com/changebody.cfm?url=/tpis/immuno/wwwHLAtyping.jsp.Cite error: There are <ref> tags on this page without content in them (see the help page).

Trowsdale, John, and Julian C. Knight. “Major Histocompatibility Complex Genomics and Human Disease.” Annual review of genomics and human genetics 14 (2013): 301–323. PMC. Web. 5 Feb. 2016.Cite error: There are <ref> tags on this page without content in them (see the help page).

Wang, E. Human leukocyte antigen and human neutrophil antigen systems. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 114.Cite error: There are <ref> tags on this page without content in them (see the help page).

Wang, Jim. Histocompatibility. S.l.: Callisto Reference, 2015.Cite error: There are <ref> tags on this page without content in them (see the help page).

Immcarle15 (talk) 00:52, 4 February 2016 (UTC)[reply]

Working summary/intro section for article[edit]

Here is a rough alternate summary as an introduction for the article. I will be adding more precise detail into the main body paragraphs later on.

Histocompatibility is the degree of similarity between live tissues, specifically in terms of the number of matching human leukocyte antigen (HLA) alleles between the two tissues. HLA is the human form of the major histocompatibility complex genes found in all vertebrates. On the population level there are thousands of known alleles for this gene with new ones being continuously discovered. Each individual inherits two different HLA alleles located on human chromosome 6. Each of these alleles contain six loci which code for major histocompatibility complex (MHC) class I and class II. These genes are codominantly expressed so every individual expresses every MHC class I and MHC class II allele, both paternal and maternal.

The similarity or difference of one individual’s alleles to another’s is what allows their tissues to match or not, thus histocompatibility is a critical criteria for whole organ as well as stem cell transplantation. Certain MHCs are present on every cell type and are a type of self-antigen. This means that the body naturally produces antibodies for their own MHC proteins. The body over time stops producing these antibodies for MHCs. Introduction of foreign tissue through transplant introduces a new set of MHCs to the body. The recipient’s immune cells will respond as normal treating the donor tissue as an antigen unless the MHCs present are similar to their own MHCs for which the immune cells have already learned to recognize and not destroy.

Histocompatibility testing has evolved greatly with the technological advances in DNA based molecular typing and solid phase immunoassays. With this technology it is possible to detect very small amounts of HLA specific antibodies within an individual. This has produced a major challenge for transplant teams as researchers are trying to find out if such small concentrations of antibodies are clinically relevant. Different regions of the world follow their own allocation schemes for organ donation, part of which includes variation in histocompatibility. Immcarle15 (talk) 04:02, 10 February 2016 (UTC)[reply]