Talk:Drug of last resort

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Pharmacology Mid‑importance

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Ciprofloxacin resistance?[edit]

The article about Ciprofloxacin says that there are strains resistant to it, but this article says there are none? --85.130.6.178 (talk) 19:42, 1 July 2006 (UTC)[reply]

Clozapine[edit]

I think this drug is appropriate here, but I don't know what kind of citation would be valid for such a subjective topic... But clozapine has all of the characteristics mentioned in the introduction to this article: better efficacy, additional side effects (seizures, agranulocytosis), and is considered an option only after multiple treatment failures in most algorithms. --128.248.141.106 (talk) 22:26, 6 June 2012 (UTC)[reply]

Vancomycin[edit]

This is laughable. About half of the patients in any given ICU are on this drug, and it is pretty well tolerated. --128.248.141.106 (talk) 22:26, 6 June 2012 (UTC)[reply]

Most restriction schemes for the use of vancomycin are because unrestricted use of it would increase the number of patients in which resistance plasmid transfer (thus resistance to what's almost an indispensable drug in the ICU setting) occurs. It's being "saved" for those patients for whom there are few other treatment alternatives (infection with MRSA, for example). And that's not laughable. loupgarous (talk) 06:16, 12 March 2014 (UTC)[reply]

68.43.179.102 (talk) 20:05, 18 January 2020 (UTC) Vancomycin is first-line therapy for many conditions. Not sure why it is listed as a drug of last resort when it is first-line for MRSA or suspected MRSA. Daptomycin and Linezolid are more appropriate drugs of last resort than Vancomycin.[reply]

"DoLR" not used in literature[edit]

I haven't seen this term—initialized or otherwise—used often in medical literature. As a result, defining it and providing examples of "drugs of last resort" will be tricky. Perhaps it would be better to describe drugs used in higher lines of therapy/treatment (LOT)? Sometimes the terms "last-line drug/therapy/treatment" and "last line of therapy" appear in literature, but are seldom used because of their implications.

"Lines of therapy" is a far more recognized term that applies to essentially all therapies and diseases that have regimented treatments—drug resistance, MDR, cross-tolerance, treatment-resistant conditions, experimental therapies/drugs, and so on. Using this term instead of "last resort" also clears up ambiguities regarding the qualifications for a drug to be considered of last resort. This is because LOTs are defined. – Vonkworm (talk) 08:16, 5 December 2020 (UTC)[reply]