Talk:Cooperative binding

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This article was adapted from Melanie I Stefan; Nicolas Le Novère (2013). "Cooperative binding". PLOS Computational Biology. 9 (6): e1003106. doi:10.1371/JOURNAL.PCBI.1003106. ISSN 1553-734X. PMC 3699289. PMID 23843752. Wikidata Q21045427.{{cite journal}}: CS1 maint: unflagged free DOI (link) after peer review (reviewer reports) under a CC BY 4.0 license (2013).

Cooperativity of binding is not always due to increased affinities[edit]

This is an often made confusion. In the Hill framework, there is absolutely no increase of affinity with the concentration of ligand. The increased binding is proportional to the concentration, but with a fixed affinity. The Hill Plot provides a straight line. This is why one cannot derive the Hill equation from Mass Action Law. The Hill equation is a nice phenomenological fit, but it requires magic to work. Even in the Adair Law, K1,2,3,4 are only phenomenological constants. It is only with Klotz that different affinities are introduced. Furthermore, other mechanisms have been proposed to explained cooperativity, for instance changes of the number of binding sites (poly- or depolymerisation). — Preceding unsigned comment added by Lenov (talk • contribs) 13:30, 31 December 2011 (UTC)[reply]

missing[edit]

It's miss Adair's & Monod's equations

Actually, it misses far more than that, including:

the discovery of cooperative binding of oxygen by Christian Bohr
the (failed) tentative of explaining using mass-action by AV Hill, resulting in the famous Hill equation
the proposition by G Adair of increasing affinities with successive bindings
the successful derivation of Adair's law using mass-action law (what Hill tried during his master thesis)
short but precise introduction of MWC (concerted) and KNF (sequential) models

Note to self: rewrite that article ... Nicolas Le Novere (talk) 13:21, 31 December 2011 (UTC)[reply]

Double up?[edit]

Isn't this and cooperativity the same topic? Do we need a merge? Richard001 06:43, 2 August 2007 (UTC)[reply]

Oh, I see, never mind... Richard001 06:45, 2 August 2007 (UTC)[reply]

No, it does not cover the same topic. Cooperativity is not limited to binding. But the other article is terrible as well. Note to self: rewrite the cooperativity article :-( Nicolas Le Novere (talk) 13:23, 31 December 2011 (UTC)[reply]

Cooperativity may not be limited to binding, but cooperative binding is a subcategory of cooperativity: a merger does seem merited to me.Mikalra (talk) 21:04, 11 November 2017 (UTC)[reply]

photo[edit]

The current photo is NOT relevant to this topic in biochemistry. I am going to undo the last edit. —Preceding unsigned comment added by 129.97.140.98 (talk) 15:44, 9 June 2008 (UTC)[reply]

Rewrite of the page[edit]

A colleague of mine and I will rewrite and extend this page, and submit it for a Topic Page of PLoS Computational Biology http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002446#pcbi.1002446-Bliven1

Will update the Wikipedia entry once it is done. Nicolas Le Novere (talk) 07:41, 30 March 2012 (UTC)[reply]

Just an update to say that the PLoS article is almost finished. Nicolas Le Novere (talk) 21:56, 3 January 2013 (UTC)[reply]

It can be found at http://topicpages.ploscompbiol.org/wiki/Cooperative_binding . Comments and suggestions welcome. -- Daniel Mietchen - WiR/OS (talk) 23:10, 9 January 2013 (UTC)[reply]

I replaced the page with the content of the PLoS topic page. Nicolas Le Novère (talk) 08:55, 28 June 2013 (UTC)[reply]