Talk:Coagulation factor VII

Physiology Mid‑importance

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Molecular Biology: MCB

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NN1731[edit]

Analogue V158D/E296V/M298Q-FVIIa, see doi:10.1111/j.1365-2141.2007.06534.x JFW | T@lk 21:42, 26 March 2007 (UTC)[reply]

'Bold text'6== Annals of Internal Medicine 2011 ==

Veronica Yank et al., Annals of Internal Medicine, 19 April 2011, meta-analysis of 64 studies of off-label use, found no evidence rFVIIa prolonged life, cost $10,000/dose, 97% off-label. --Nbauman (talk) 19:58, 24 May 2011 (UTC)[reply]

Image?[edit]

Is there an image of the coagulation cascade that could be inserted so that we know where this is? — Preceding unsigned comment added by 137.43.188.169 (talk) 17:33, 3 May 2012 (UTC)[reply]

Assessment comment[edit]

The comment(s) below were originally left at Talk:Coagulation factor VII/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Comment(s)

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I would also like to see the addion of the calcium and phospholipid requirements for the formation of the VIIa + TF complex, or as I call it, E-Tenase (I know its not really a Tenase but it does the same job). Also the localization onto platelet surface. This will help explaing how clotting stays localized to those who have trouble understanding how a non-sentient system that relies on probability could seem so intelligently orchestrated. If the Ultimate goal is to be understandable to those with a Secondary Education then I feel it is very important to show how it is that biological systems "think" because homeostasis (and more specifically hemostasis here) can look suspiciously like an intelligent system if isn't explained how exaclty the mechanisms localize and feed back. Also the omission of those requirements for VIIa-TF complex is quite large as knowing where phospholipids are used as a part of the coagulation cascade is intrinsic to understanding the sites that Lupus Anticoagluants, and anti-phospholibid antibodies will affect. I left this comment with the Tissue Factor page as well (with slightly less content). 170.173.0.16 (talk) 19:25, 27 February 2009 (UTC)[reply]

Last edited at 19:25, 27 February 2009 (UTC). Substituted at 14:54, 29 April 2016 (UTC)