Talk:Antisense therapy

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note[edit]

Regarding the statement:

This synthesized DNA is termed "anti-sense" DNA because its base sequence is the opposite of the gene's messenger RNA (so that a segment "AAGGTC" would be blocked by the anti-sense segment "TTCCAG"). These potential therapies have not yet produced significant clinical results.

Since the convention is to write any single nucleic acid strand in 5' to 3' orientation, the segment "AAGGTC" is not complementary to the segment "TTCCAG". Instead, the complement of "AAGGTC" is "GACCTT". It is acceptable to write a single strand in 3' to 5' orientation if it is clearly marked, so I have added orientation marks: "5'-AAGGTC-3'" and "3'-TTCCAG-5'". Keeping the second strand antiparallel with the first strand may make this more understandable to those unused to reading sense and antisense in opposite directions when looking for complementarity. subst:unsigned

Merge[edit]

I support the merge. ViridaeTalk 07:01, 22 August 2006 (UTC)[reply]

  • As no-one objected, I've merged with Antisense drugs. I've attempted to meld the two wordings, but this isn't my area of expertise so if I've made mistakes please correct them! Espresso Addict 03:32, 26 August 2006 (UTC)[reply]

I think the merge will dilute the history and consequence of the technology to mankind! PLEASE DONT

How related to RNA interference[edit]

How is Antisense therapy related to RNA interference (RNAi) ? Rod57 (talk) 03:52, 24 January 2009 (UTC)[reply]

... Antisense RNA says it uses single strand RNA whereas RNAi uses double-strand RNA. Rod57 (talk) 08:47, 6 August 2010 (UTC)[reply]

Proposed merge with Antisense RNA[edit]

I oppose this propsed merge. Antisense therapy is not a subset of antisense RNA. Many antisense therapies currently under development use DNA-based molecules. The merge was proposed a year ago so I'm deleting the template. Dubbinu | t | c 11:13, 9 May 2016 (UTC)[reply]

External links modified[edit]

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External links modified[edit]

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Orphaned references in Antisense therapy[edit]

I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Antisense therapy's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.

Reference named "FDA Snapshot":

  • From Inotersen: "Drug Trial Snapshot: Tegsedi". U.S. Food and Drug Administration (FDA). 23 July 2019. Archived from the original on 19 December 2019. Retrieved 18 December 2019. Public Domain This article incorporates text from this source, which is in the public domain.
  • From Golodirsen: "Drug Trials Snapshots: Vyondys 53". U.S. Food and Drug Administration (FDA). 12 December 2019. Retrieved 24 January 2020. Public Domain This article incorporates text from this source, which is in the public domain.

I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 05:09, 7 July 2020 (UTC)[reply]

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