TBCB

TBCB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V6E, 1WHG
Identifiers
Aliases	TBCB, CG22, CKAP1, CKAPI, tubulin folding cofactor B
External IDs	OMIM: 601303 MGI: 1913661 HomoloGene: 981 GeneCards: TBCB
Gene location (Human)
Chr.	Chromosome 19 (human)
End	36,125,947 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	29,931,697 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; pons; ; prefrontal cortex; ; middle frontal gyrus; ; inferior olivary nucleus; ; hypothalamus; ; substantia nigra; ; superior vestibular nucleus; ; amygdala; ; Brodmann area 9;
	Top expressed in
	facial motor nucleus; ; barrel cortex; ; anterior horn of spinal cord; ; superior cervical ganglion; ; motor neuron; ; medial ganglionic eminence; ; medullary collecting duct; ; maxillary prominence; ; endocardial cushion; ; optic nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule cytoskeleton; microtubule; cytoskeleton; cytosol;
Biological process	multicellular organism development; cell differentiation; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	1155
	66411
	ENSG00000105254
	ENSMUSG00000006095
	Q99426
	Q9D1E6
	NM_001300971; NM_001281
	NM_025548; NM_001360648; NM_001360649
	NP_001272; NP_001287900
	NP_079824; NP_001347577; NP_001347578
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin-folding cofactor B is a protein that in humans is encoded by the TBCB gene.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105254 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006095 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watanabe TK, Shimizu F, Nagata M, Kawai A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Jan 1997). "Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain". Cytogenet Cell Genet. 72 (2–3): 208–11. doi:10.1159/000134191. PMID 8978778.
^ "Entrez Gene: TBCB tubulin folding cofactor B".

Further reading[edit]

Wolz W, Wendelmuth U, Rouquier S, et al. (1997). "A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1)". Cytogenet. Cell Genet. 72 (2–3): 215–6. doi:10.1159/000134193. PMID 8978780.
Tian G, Lewis SA, Feierbach B, et al. (1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors". J. Cell Biol. 138 (4): 821–32. doi:10.1083/jcb.138.4.821. PMC 2138046. PMID 9265649.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Vadlamudi RK, Barnes CJ, Rayala S, et al. (2005). "p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B". Mol. Cell. Biol. 25 (9): 3726–36. doi:10.1128/MCB.25.9.3726-3736.2005. PMC 1084301. PMID 15831477.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Wang W, Ding J, Allen E, et al. (2006). "Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway". Curr. Biol. 15 (22): 2050–5. doi:10.1016/j.cub.2005.10.052. PMID 16303566.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105254 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006095 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978778-5] Watanabe TK, Shimizu F, Nagata M, Kawai A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Jan 1997). "Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain". Cytogenet Cell Genet. 72 (2–3): 208–11. doi:10.1159/000134191. PMID 8978778.

[entrez-6] "Entrez Gene: TBCB tubulin folding cofactor B".

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