ST6GALNAC6

ST6GALNAC6
Identifiers
Aliases	ST6GALNAC6, SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
External IDs	OMIM: 610135 MGI: 1355316 HomoloGene: 8390 GeneCards: ST6GALNAC6
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.11 Start 127,885,321 bp End 127,905,408 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 32,489,721 bp End 32,510,818 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala nucleus accumbens putamen caudate nucleus hippocampus proper rectum right coronary artery dorsolateral prefrontal cortex popliteal artery prefrontal cortex Top expressed in left colon superior frontal gyrus cerebellar cortex right ventricle olfactory tubercle ciliary body piriform cortex lateral hypothalamus prefrontal cortex subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity sialyltransferase activity alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane plasma membrane Golgi membrane cytoplasm Biological process cell-cell recognition glycoprotein metabolic process glycosphingolipid metabolic process protein glycosylation glycosylceramide metabolic process oligosaccharide metabolic process sialylation protein N-linked glycosylation via asparagine ganglioside biosynthetic process oligosaccharide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30815 50935 Ensembl ENSG00000160408 ENSMUSG00000026811 UniProt Q969X2 Q9JM95 RefSeq (mRNA) NM_001286999 NM_001287000 NM_001287001 NM_001287002 NM_001287003 NM_013443 NM_001388489 NM_001025310 NM_001025311 NM_001289547 NM_001289548 NM_001289549 NM_016973 RefSeq (protein) NP_001273928 NP_001273929 NP_001273930 NP_001273931 NP_001273932 NP_038471 NP_001020481 NP_001020482 NP_001276476 NP_001276477 NP_001276478 NP_058669 Location (UCSC) Chr 9: 127.89 – 127.91 Mb Chr 2: 32.49 – 32.51 Mb PubMed search
Wikidata
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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.

Further reading

• Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573. PMID 17123352.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi:10.1074/jbc.275.10.6717. PMID 10702226.