Mitochondrial uncoupling protein 4

SLC25A27
Identifiers
Aliases	SLC25A27, solute carrier family 25, member 27, UCP4, solute carrier family 25 member 27
External IDs	OMIM: 613725 MGI: 1921261 HomoloGene: 12523 GeneCards: SLC25A27
Gene location (Human) Chr. Chromosome 6 (human) Band 6p12.3 Start 46,652,915 bp End 46,678,190 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B3 Start 43,641,891 bp End 43,667,214 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa anterior pituitary right uterine tube cerebellar hemisphere left lobe of thyroid gland right lobe of thyroid gland canal of the cervix Brodmann area 9 tibial nerve Achilles tendon Top expressed in hand otolith organ utricle superior cervical ganglion superior frontal gyrus visual cortex ganglionic eminence cerebellar cortex neural tube olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane transporter activity Cellular component membrane apical part of cell neuronal cell body mitochondrion mitochondrial inner membrane integral component of membrane mitochondrial membranes Biological process negative regulation of mitochondrial calcium ion concentration cellular triglyceride homeostasis positive regulation of cell population proliferation regulation of glucose import neuron death negative regulation of mitochondrial membrane potential inner ear development negative regulation of apoptotic process mitochondrial transport response to cold regulation of mitochondrial membrane potential transmembrane transport proton transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9481 74011 Ensembl ENSG00000153291 ENSMUSG00000023912 UniProt O95847 Q9D6D0 RefSeq (mRNA) NM_001204051 NM_001204052 NM_004277 NM_028711 NM_001357122 NM_001357123 RefSeq (protein) NP_001190980 NP_001190981 NP_004268 NP_082987 NP_001344051 NP_001344052 Location (UCSC) Chr 6: 46.65 – 46.68 Mb Chr 17: 43.64 – 43.67 Mb PubMed search
Wikidata
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Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are detected only in brain tissue and are specifically modulated by various environmental conditions. Recently, the proton transport activity of UCP4 has also been shown to be activated by fatty acids and inhibited by purine nucleotides. In addition, reconstituted UCP4 exhibited a distinct conformation, compared to other UCPs in the family.

See also

• Solute carrier family
• Uncoupling protein

Further reading

• Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". Biochem. J. 345 (2): 161–79. doi:10.1042/0264-6021:3450161. PMC 1220743. PMID 10620491.
• Muzzin P (2002). "The uncoupling proteins". Ann. Endocrinol. 63 (2 Pt 1): 106–10. PMID 11994670.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Yu XX, Mao W, Zhong A, et al. (2000). "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation". FASEB J. 14 (11): 1611–8. doi:10.1096/fj.14.11.1611. PMID 10928996.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Liu D, Chan SL, de Souza-Pinto NC, et al. (2007). "Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress". Neuromolecular Med. 8 (3): 389–414. doi:10.1385/NMM:8:3:389. PMID 16775390. S2CID 7377782.
• Chan SL, Liu D, Kyriazis GA, et al. (2007). "Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells". J. Biol. Chem. 281 (49): 37391–403. doi:10.1074/jbc.M605552200. PMID 17035241.
• Yasuno K, Ando S, Misumi S, et al. (2007). "Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 250–3. doi:10.1002/ajmg.b.30443. PMID 17066476. S2CID 30129988.
• Ho PW, Ho JW, Tse HM, et al. (2012). "Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells". PLOS ONE. 7 (2): e32810. Bibcode:2012PLoSO...732810H. doi:10.1371/journal.pone.0032810. PMC 3303587. PMID 22427795.
• Ho JW, Ho PW, Liu HF, et al. (2012). "UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress". Free Radic Biol Med. 53 (2): 383–394. doi:10.1016/j.freeradbiomed.2012.05.002. PMID 22580300.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.