Phospholipase A-2-activating protein

PLAA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K89, 2K8A, 2K8B, 2K8C, 3EBB
Identifiers
Aliases	PLAA, DOA1, PLA2P, PLAP, phospholipase A2 activating protein, NDMSBA
External IDs	OMIM: 603873 MGI: 104810 HomoloGene: 3138 GeneCards: PLAA
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.2 Start 26,903,372 bp End 26,947,242 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C5|4 43.34 cM Start 94,455,751 bp End 94,491,481 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle secondary oocyte stromal cell of endometrium ganglionic eminence monocyte Achilles tendon islet of Langerhans left adrenal gland rectum left ventricle Top expressed in secondary oocyte medial ganglionic eminence primitive streak somite maxillary prominence atrioventricular valve abdominal wall morula seminal vesicula knee joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phospholipase A2 activator activity ubiquitin binding Cellular component extracellular exosome cytoplasm nucleus synapse cell junction Biological process phospholipid metabolic process inflammatory response signal transduction ubiquitin recycling proteasome-mediated ubiquitin-dependent protein catabolic process macroautophagy ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway cellular response to lipopolysaccharide negative regulation of protein K63-linked ubiquitination positive regulation of synaptic vesicle recycling positive regulation of dendrite extension positive regulation of neuron migration prostaglandin metabolic process multicellular organism development nervous system development positive regulation of phospholipase A2 activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9373 18786 Ensembl ENSG00000137055 ENSMUSG00000028577 UniProt Q9Y263 P27612 RefSeq (mRNA) NM_001031689 NM_004253 NM_001321546 NM_172695 RefSeq (protein) NP_001026859 NP_001308475 NP_766283 Location (UCSC) Chr 9: 26.9 – 26.95 Mb Chr 4: 94.46 – 94.49 Mb PubMed search
Wikidata
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Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.

Further reading

• Clark MA, Ozgür LE, Conway TM, et al. (1991). "Cloning of a phospholipase A2-activating protein". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5418–22. Bibcode:1991PNAS...88.5418C. doi:10.1073/pnas.88.12.5418. PMC 51884. PMID 2052621.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ruiz A, Nadal M, Puig S, Estivill X (1999). "Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region". Gene. 239 (1): 155–61. doi:10.1016/S0378-1119(99)00354-6. PMID 10571045.
• Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMC 99970. PMID 11689694.
• Kozlenkov A, Manes T, Hoylaerts MF, Millán JL (2002). "Function assignment to conserved residues in mammalian alkaline phosphatases". J. Biol. Chem. 277 (25): 22992–9. doi:10.1074/jbc.M202298200. PMID 11937510.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Koumanov K, Momchilova A, Wolf C (2004). "Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2". Cell Biol. Int. 27 (10): 871–7. doi:10.1016/S1065-6995(03)00176-8. PMID 14499668. S2CID 10953531.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.