PCDHB14

PCDHB14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYJ
Identifiers
Aliases	PCDHB14, PCDH-BETA14, protocadherin beta 14
External IDs	OMIM: 606340 MGI: 2136758 HomoloGene: 134303 GeneCards: PCDHB14
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.3 Start 141,223,343 bp End 141,227,759 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B3 Start 37,637,317 bp End 37,640,875 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence lactiferous duct ascending aorta Achilles tendon prefrontal cortex endothelial cell left coronary artery right coronary artery Brodmann area 9 stromal cell of endometrium Top expressed in cerebellar cortex superior frontal gyrus hippocampus proper ganglionic eminence neural tube mesencephalon olfactory bulb uterus lens hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding protein binding Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56122 93891 Ensembl ENSG00000120327 ENSMUSG00000046191 UniProt Q9Y5E9 Q91XZ9 RefSeq (mRNA) NM_018934 NM_053145 RefSeq (protein) NP_061757 NP_444375 Location (UCSC) Chr 5: 141.22 – 141.23 Mb Chr 18: 37.64 – 37.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome 5. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections.

Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Frank M, Kemler R (2003). "Protocadherins". Curr. Opin. Cell Biol. 14 (5): 557–62. doi:10.1016/S0955-0674(02)00365-4. PMID 12231349.
• Matsuyoshi N, Tanaka T, Toda K, Imamura S (1997). "Identification of novel cadherins expressed in human melanoma cells". J. Invest. Dermatol. 108 (6): 908–13. doi:10.1111/1523-1747.ep12292703. PMID 9182820.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
• Vanhalst K, Kools P, Vanden Eynde E, van Roy F (2001). "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number". FEBS Lett. 495 (1–2): 120–5. doi:10.1016/S0014-5793(01)02372-9. PMID 11322959. S2CID 36671435.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.