PCDH18

PCDH18
Identifiers
Aliases	PCDH18, PCDH68L, protocadherin 18
External IDs	OMIM: 608287 MGI: 1920423 HomoloGene: 10389 GeneCards: PCDH18
Gene location (Human) Chr. Chromosome 4 (human) Band 4q28.3 Start 137,518,918 bp End 137,532,494 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 C Start 49,697,745 bp End 49,711,774 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium Achilles tendon parietal pleura lactiferous duct retinal pigment epithelium tibia placenta visceral pleura tibialis anterior muscle endothelial cell Top expressed in hand maxillary prominence dermis left lung lobe molar foot abdominal wall body of femur vas deferens belly cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process brain development homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54510 73173 Ensembl ENSG00000189184 ENSMUSG00000037892 UniProt Q9HCL0 Q8VHR0 RefSeq (mRNA) NM_001300828 NM_019035 NM_130448 RefSeq (protein) NP_001287757 NP_061908 NP_569715 NP_001391291 NP_001391292 NP_001391293 NP_001391295 NP_001391296 NP_001391306 Location (UCSC) Chr 4: 137.52 – 137.53 Mb Chr 3: 49.7 – 49.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.

Further reading

• Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Homayouni R, Rice DS, Curran T (2002). "Disabled-1 interacts with a novel developmentally regulated protocadherin". Biochem. Biophys. Res. Commun. 289 (2): 539–47. doi:10.1006/bbrc.2001.5998. PMID 11716507.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.