NREP

NREP
Identifiers
Aliases	NREP, C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17, neuronal regeneration related protein
External IDs	OMIM: 607332 MGI: 99444 HomoloGene: 70874 GeneCards: NREP
Gene location (Human)
Chr.	Chromosome 5 (human)
End	111,997,464 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	33,597,082 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; tibia; ; pons; ; Brodmann area 46; ; frontal pole; ; Brodmann area 10; ; biceps brachii; ; orbitofrontal cortex; ; endothelial cell; ; dorsolateral prefrontal cortex;
	Top expressed in
	external carotid artery; ; cerebellar vermis; ; fossa; ; barrel cortex; ; condyle; ; internal carotid artery; ; trigeminal ganglion; ; ureter; ; medullary collecting duct; ; ganglionic eminence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of neuron differentiation; axon regeneration; regulation of transforming growth factor beta receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9315
	27528
	ENSG00000134986
	ENSMUSG00000042834
	Q16612
	Q07475
NM_001142474; NM_001142475; NM_001142476; NM_001142477; NM_001142478;
	NM_001142479; NM_001142480; NM_001142481; NM_001142482; NM_001142483; NM_004772
	NM_001109988; NM_001109989; NM_001267717; NM_053078
NP_001135946; NP_001135947; NP_001135948; NP_001135949; NP_001135950;
	NP_001135951; NP_001135952; NP_001135953; NP_001135954; NP_001135955; NP_004763
	NP_001103458; NP_001103459; NP_001254646; NP_444308
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal protein 3.1 is a protein that in humans is encoded by the NREP gene.^[5]^[6]^[7] It is highly expressed in the brain.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134986 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042834 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Studler JM, Glowinski J, Lévi-Strauss M (Jun 1993). "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood". The European Journal of Neuroscience. 5 (6): 614–23. doi:10.1111/j.1460-9568.1993.tb00527.x. PMID 8261136. S2CID 35425949.
^ Miura N, Naganuma A (Aug 2000). "Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure". FEBS Letters. 479 (3): 146–8. doi:10.1016/S0014-5793(00)01899-8. PMID 10981724. S2CID 9344664.
^ "Entrez Gene: C5orf13 chromosome 5 open reading frame 13".
^ "Human Gene NREP (ENST00000447165.6) Description and Page Index". genome.ucsc.edu.

External links[edit]

Human NREP genome location and NREP gene details page in the UCSC Genome Browser.

Further reading[edit]

Taylor GA, Hudson E, Resau JH, Vande Woude GF (Feb 2000). "Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system". The Journal of Biological Chemistry. 275 (6): 4215–9. doi:10.1074/jbc.275.6.4215. PMID 10660586.
Pan D, Zhe X, Jakkaraju S, Taylor GA, Schuger L (Nov 2002). "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype". The Journal of Clinical Investigation. 110 (9): 1349–58. doi:10.1172/JCI15614. PMC 151607. PMID 12417574.
McDonough WS, Tran NL, Berens ME (Sep 2005). "Regulation of glioma cell migration by serine-phosphorylated P311". Neoplasia. 7 (9): 862–72. doi:10.1593/neo.05190. PMC 1501936. PMID 16229809.
Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH (Jul 2006). "Identification of P311 as a potential gene regulating alveolar generation". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 48–54. doi:10.1165/rcmb.2005-0475OC. PMC 2658697. PMID 16484684.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134986 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042834 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8261136-5] Studler JM, Glowinski J, Lévi-Strauss M (Jun 1993). "An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood". The European Journal of Neuroscience. 5 (6): 614–23. doi:10.1111/j.1460-9568.1993.tb00527.x. PMID 8261136. S2CID 35425949.

[pmid10981724-6] Miura N, Naganuma A (Aug 2000). "Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure". FEBS Letters. 479 (3): 146–8. doi:10.1016/S0014-5793(00)01899-8. PMID 10981724. S2CID 9344664.

[entrez-7] "Entrez Gene: C5orf13 chromosome 5 open reading frame 13".

[8] "Human Gene NREP (ENST00000447165.6) Description and Page Index". genome.ucsc.edu.

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