NOL6

NOL6
Identifiers
Aliases	NOL6, NRAP, UTP22, bA311H10.1, nucleolar protein 6
External IDs	OMIM: 611532 MGI: 2140151 HomoloGene: 41505 GeneCards: NOL6
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 33,461,353 bp End 33,473,930 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 41,114,427 bp End 41,124,455 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skin of abdomen anterior pituitary body of pancreas islet of Langerhans stromal cell of endometrium upper lobe of left lung left uterine tube right lobe of thyroid gland right adrenal gland Top expressed in superior frontal gyrus right ventricle yolk sac cerebellar cortex lip dorsomedial hypothalamic nucleus morula submandibular gland subiculum olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component condensed nuclear chromosome small-subunit processome nucleolus mitochondrion nucleus CURI complex chromosome UTP-C complex nucleoplasm Biological process tRNA export from nucleus rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65083 230082 Ensembl ENSG00000165271 ENSMUSG00000028430 UniProt Q9H6R4 Q8R5K4 RefSeq (mRNA) NM_139235 NM_022917 NM_130793 NM_139236 NM_139237 RefSeq (protein) NP_075068 NP_631981 NP_631982 Location (UCSC) Chr 9: 33.46 – 33.47 Mb Chr 4: 41.11 – 41.12 Mb PubMed search
Wikidata
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Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.

Further reading

• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.