Julie Law

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Julie Law
Alma materOregon State University (B.S.)

Johns Hopkins School of Medicine (Ph.D.)

University of California, Los Angeles (Postdoctoral fellow)
Known forDiscovery of protein family that controls DNA methylation
AwardsRuth L. Kirschstein National Research Service Award, Rita Allen Scholar, Newsweek magazine “Women of the Future” nominee
Scientific career
FieldsPlant Molecular and Cellular Biology, Epigenetics, Chromatin Based Processes
InstitutionsSalk Institute for Biological Studies
Doctoral advisorDr. Barbara Sollner-Webb

Julie Law (born c. ) is an American molecular and cellular biologist.[1] Law's pioneering work on DNA methylation patterns led to the discovery of the role of the CLASSY protein family in DNA methylation.[2] Law is currently an associate professor at the Salk Institute for Biological Studies.[3]

Early life and education[edit]

Law began her scientific career at the Oregon State University where she completed a B.S. in biochemistry and biophysics.[4] She completed her undergraduate research in the laboratory of Dr. Walt Ream.[4] studying plant-microbe interactions[5] She moved to the east coast to complete her doctoral work in biochemistry at Johns Hopkins School of Medicine under the mentorship of Dr. Barbara Sollner-Webb[4] Law's Ph.D. work uncovered the unique RNA editing mechanisms used by pathogenic eukaryotes called trypanosomes.[6] Following her doctoral work, Law moved back to the west coast to pursue postdoctoral training at the University of California, Los Angeles in the lab of Dr. Steven Jacobsen,[4] where she studied DNA methylation in Arabidopsis, a common model organism in biology allowing her to study epigenetic regulation.[7]

Career and research[edit]

Law's postdoctoral work, studying DNA methylation at UC Los Angeles, was followed by her recruitment for a faculty position at the Salk Institute for Biological Studies in 2012.[4] Currently, Law's lab at the Salk Institute studies epigenetic modifications in Arabidopsis thaliana to probe how epigenetic tags are recognized by proteins to regulate gene expression.[8] Law is currently working with several other Salk scientists as a part of the Harnessing Plants Initiative to engineer plants to store more carbon dioxide as a means to harness more carbon dioxide from the atmosphere to combat climate change.[9]

Publications[edit]

Selected publications:[10]

  • Wu, S., Turner, K.M., Nguyen, N., Raviram, R., Erb, M., Santini, J., Luebeck, J., Rajkumar, U., Diao, Y., Li, B., Zhang, W., Jameson, N., Corces, M.R., Granja, J.M., Chen, X., Coruh, C., Abnousi, A., Houston, J., Ye, Z., Hu, R., Yu, M., Kim, H., Law, J.A., Verhaak, R.G.W., Hu, M., Furnari, F.B., Chang, H.Y., Ren, B., Bafna, V., Mischel, P.S. Circular ecDNA promotes accessible chromatin and high oncogene expression. (2019) Nature. 575(7784):699-703. DOI: 10.1038/s41586-019-1763-5
  • Argueso, C.T., Assmann, S.M., Birnbaum, K.D., Chen, S., Dinneny, J.R., Doherty, C.J., Eveland, A.L., Friesner, J., Greenlee, V.R., Law, J.A., Marshall-Colón, A., Mason, G.A., O'Lexy, R., Peck, S.C., Schmitz, R.J., Song, L., Stern, D., Varagona, M.J., Walley, J.W., Williams, C.M. Directions for research and training in plant omics: Big Questions and Big Data. (2019) Plant Direct. 3(4):e00133. DOI: 10.1002/pld3.133
  • Bourbousse, C., Vegesna, N., Law, J.A. SOG1 activator and MYB3R repressors regulate a complex DNA damage network in . (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1810582115
  • Zhou, M., Palanca, A.M.S., Law, J.A. Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family. (2018) Nature Genetics. 50(6). DOI: 10.1038/s41588-018-0115-y
  • Li, D., Palanca, A.M.S., Won, S.Y., Gao, L., Feng, Y., Vashisht, A.A., Liu, L., Zhao, Y., Liu, X., Wu, X., Li, S., Le, B., Kim, Y.J., Yang, G., Li, S., Liu, J., Wohlschlegel, J.A., Guo, H., Mo, B., Chen, X., Law, J.A. The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. (2017) Elife. 6. DOI: 10.7554/eLife.19893
  • Zhou, M., Law, J.A. RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules. (2015) Current Opinion in Plant Biology. 27:154-64. DOI: 10.1016/j.pbi.2015.07.005
  • Law, J.A., Du, J., Hale, C.J., Feng, S., Krajewski, K., Palanca, A.M., Strahl, B.D., Patel, D.J., Jacobsen, S.E. Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. (2013) Nature. 498(7454):385-9. DOI: 10.1038/nature12178
  • Zhong, X., Hale, C.J., Law, J.A., Johnson, L.M., Feng, S., Tu, A., Jacobsen, S.E. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. (2012) Nature Structural & Molecular Biology. 19(9):870-5. DOI: 10.1038/nsmb.2354
  • Law, J.A., Vashisht, A.A., Wohlschlegel, J.A., Jacobsen, S.E. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. (2011) PLOS Genetics. 7(7):e1002195. DOI: 10.1371/journal.pgen.1002195
  • Greenberg, M.V., Ausin, I., Chan, S.W., Cokus, S.J., Cuperus, J.T., Feng, S., Law, J.A., Chu, C., Pellegrini, M., Carrington, J.C., Jacobsen, S.E. Identification of genes required for de novo DNA methylation in Arabidopsis. (2011) Epigenetics. 6(3):344-54.
  • Rajakumara, E., Law, J.A., Simanshu, D.K., Voigt, P., Johnson, L.M., Reinberg, D., Patel, D.J., Jacobsen, S.E. A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. (2011) Genes & Development. 25(2):137-52. DOI: 10.1101/gad.1980311
  • Guo, L., Yu, Y., Law, J.A., Zhang, X. SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(43):18557-62. DOI: 10.1073/pnas.1010478107
  • Law, J.A., Ausin, I., Johnson, L.M., Vashisht, A.A., Zhu, J.K., Wohlschlegel, J.A., Jacobsen, S.E. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. (2010) Current Biology. 20(10):951-6. DOI: 10.1016/j.cub.2010.03.062
  • Law, J.A., Jacobsen, S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. (2010) Nature Reviews. Genetics. 11(3):204-20. DOI: 10.1038/nrg2719
  • Law, J.A., Jacobsen, S.E. Molecular biology. Dynamic DNA methylation. (2009) Science. 323(5921):1568-9. DOI: 10.1126/science.1172782
  • Johnson, L.M., Law, J.A., Khattar, A., Henderson, I.R., Jacobsen, S.E. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. (2008) PLOS Genetics. 4(11):e1000280. DOI: 10.1371/journal.pgen.1000280

Awards[edit]

Law has received the following awards:[11]

References[edit]

  1. ^ "Salk promotes Nicola Allen and Julie Law to associate professor". Salk Institute for Biological Studies. Retrieved 2019-08-16.
  2. ^ "Understanding how DNA is selectively tagged with "do not use" marks". Salk Institute for Biological Studies. Retrieved 2019-08-16.
  3. ^ "Julie Law". Salk Institute for Biological Studies. Retrieved 2019-08-16.
  4. ^ a b c d e "Julie Law - Rita Allen Foundation". August 1, 2016. Retrieved 2019-08-17.
  5. ^ "Dr. Walt Ream | Department of Microbiology | Oregon State University". microbiology.science.oregonstate.edu. Retrieved 2019-08-17.
  6. ^ Sollner-Webb, Barbara; O'Hearn, Sean F.; Huang, Catherine E.; Law, Julie A. (2005-04-01). "In Trypanosoma brucei RNA Editing, Band II Enables Recognition Specifically at Each Step of the U Insertion Cycle". Molecular and Cellular Biology. 25 (7): 2785–2794. doi:10.1128/MCB.25.7.2785-2794.2005. ISSN 0270-7306. PMC 1061641. PMID 15767682.
  7. ^ Jacobsen, Steven E.; Law, Julie A. (2009-03-20). "Dynamic DNA Methylation". Science. 323 (5921): 1568–1569. doi:10.1126/science.1172782. ISSN 0036-8075. PMID 19299607. S2CID 46619297.
  8. ^ "Julie Law". Salk Institute for Biological Studies. Retrieved 2020-03-14.
  9. ^ Sauer, Mark; Burke, Megan (17 April 2019). "Salk Scientists Plan To Combat Climate Change With Plants". KPBS Public Media. Retrieved 2020-03-14.
  10. ^ "Publications". Salk Institute for Biological Studies. Retrieved 2020-03-14.
  11. ^ "Julie Law". Salk Institute for Biological Studies. Retrieved 2019-08-17.

External links[edit]

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