CHMP5

CHMP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LXM, 3ULY, 3UM0, 3UM1, 3UM2, 4TXR
Identifiers
Aliases	CHMP5, C9orf83, HSPC177, PNAS-2, SNF7DC2, Vps60, CGI-34, charged multivesicular body protein 5
External IDs	OMIM: 610900 MGI: 1924209 HomoloGene: 5757 GeneCards: CHMP5
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	40,965,303 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; palpebral conjunctiva; ; amniotic fluid; ; visceral pleura; ; sperm; ; parietal pleura; ; bronchial epithelial cell; ; endothelial cell; ; jejunal mucosa; ; glomerulus;
	Top expressed in
	right lung lobe; ; pineal gland; ; superior cervical ganglion; ; facial motor nucleus; ; medial ganglionic eminence; ; conjunctival fornix; ; anterior horn of spinal cord; ; gastric mucosa; ; motor neuron; ; mucous cell of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cadherin binding;
Cellular component	cytoplasm; cytosol; endosome; membrane; endosome membrane; extracellular exosome; nucleus;
Biological process	regulation of centrosome duplication; viral life cycle; nucleus organization; multivesicular body sorting pathway; endosome to lysosome transport; multivesicular body assembly; regulation of mitotic spindle assembly; endosomal transport; protein transport; septum digestion after cytokinesis; mitotic metaphase plate congression; regulation of receptor recycling; lysosome organization; vacuolar transport; ESCRT III complex disassembly; transport; midbody abscission; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide;
	Sources:Amigo / QuickGO
Orthologs
	51510
	76959
	n/a
	ENSMUSG00000028419
	Q9NZZ3
	Q9D7S9
	NM_016410; NM_001195536
	NM_029814
	NP_001182465; NP_057494
	NP_084090
	Wikidata
View/Edit Human	View/Edit Mouse

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.^[4]^[5]^[6]

Function[edit]

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.^[6]^[7]

References[edit]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028419 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.
^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
^ ^a ^b "Entrez Gene: CHMP5 chromatin modifying protein 5".
^ Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

External links[edit]

Human CHMP5 genome location and CHMP5 gene details page in the UCSC Genome Browser.

Further reading[edit]

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028419 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15644320-4] Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.

[pmid11559748-5] Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.

[entrez-6] "Entrez Gene: CHMP5 chromatin modifying protein 5".

[pmid16730941-7] Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

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