CDK5RAP3

CDK5RAP3
Identifiers
Aliases	CDK5RAP3, C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit associated protein 3
External IDs	OMIM: 608202 MGI: 1933126 HomoloGene: 12718 GeneCards: CDK5RAP3
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 47,967,810 bp End 47,981,781 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 96,798,252 bp End 96,807,322 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland right uterine tube anterior pituitary right lobe of thyroid gland body of pancreas left lobe of thyroid gland spleen fundus prostate body of stomach Top expressed in lacrimal gland yolk sac molar parotid gland left lobe of liver seminal vesicula spermatocyte spermatid islet of Langerhans primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MDM2/MDM4 family protein binding NF-kappaB binding mitogen-activated protein kinase binding protein binding ubiquitin-like protein ligase binding protein kinase binding cyclin binding Cellular component cytoplasm centrosome membrane microtubule organizing center nucleolus microtubule cytoskeleton endomembrane system nucleus cytosol protein-containing complex Biological process negative regulation of protein phosphorylation regulation of neuron differentiation protein ufmylation positive regulation of signal transduction by p53 class mediator regulation of phosphatase activity endoplasmic reticulum unfolded protein response mitotic G2/M transition checkpoint brain development apoptotic nuclear changes negative regulation of MAP kinase activity positive regulation of ubiquitin-dependent protein catabolic process negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of protein serine/threonine kinase activity cell population proliferation mitotic G2 DNA damage checkpoint signaling negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination positive regulation of transcription by RNA polymerase II positive regulation of protein localization to nucleus regulation of cyclin-dependent protein serine/threonine kinase activity regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80279 80280 Ensembl ENSG00000108465 ENSMUSG00000018669 UniProt Q96JB5 Q99LM2 RefSeq (mRNA) NM_001278197 NM_001278198 NM_001278216 NM_001278217 NM_025197 NM_176095 NM_176096 NM_030248 NM_001308183 NM_001363255 NM_001363256 RefSeq (protein) NP_001265126 NP_001265127 NP_001265145 NP_001265146 NP_788276 NP_001295112 NP_084524 NP_001350184 NP_001350185 Location (UCSC) Chr 17: 47.97 – 47.98 Mb Chr 11: 96.8 – 96.81 Mb PubMed search
Wikidata
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CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
• Ching YP, Pang AS, Lam WH, et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
• Chen J, Liu B, Liu Y, et al. (2002). "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart". Biochem. Biophys. Res. Commun. 294 (1): 161–6. doi:10.1016/S0006-291X(02)00446-1. PMID 12054757.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xie YH, He XH, Tang YT, et al. (2003). "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein". Cell Res. 13 (2): 83–91. doi:10.1038/sj.cr.7290153. PMID 12737517. S2CID 22264922.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cen H, Zheng S, Fang YM, et al. (2004). "Induction of HSF1 expression is associated with sporadic colorectal cancer". World J. Gastroenterol. 10 (21): 3122–6. doi:10.3748/wjg.v10.i21.3122. PMC 4611254. PMID 15457556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jiang H, Luo S, Li H (2005). "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint". J. Biol. Chem. 280 (21): 20651–9. doi:10.1074/jbc.M413431200. PMID 15790566.
• Yin X, Warner DR, Roberts EA, et al. (2005). "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53". Int. J. Mol. Med. 16 (2): 251–6. doi:10.3892/ijmm.16.2.251. PMID 16012757.
• Wang J, He X, Luo Y, Yarbrough WG (2006). "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2". Biochem. J. 393 (Pt 2): 489–501. doi:10.1042/BJ20050960. PMC 1360699. PMID 16173922.
• Kim E, Chen F, Wang CC, Harrison LE (2006). "CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation". Int. J. Oncol. 28 (1): 191–4. doi:10.3892/ijo.28.1.191. PMID 16327995.
• Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677. S2CID 25119660.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Stav D, Bar I, Sandbank J (2007). "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma". Int. J. Biol. Markers. 22 (2): 108–13. doi:10.5301/jbm.2008.3142. PMID 17549666.
• Wang J, An H, Mayo MW, et al. (2007). "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB". Cancer Cell. 12 (3): 239–51. doi:10.1016/j.ccr.2007.07.002. PMID 17785205.

External links

• Human CDK5RAP3 genome location and CDK5RAP3 gene details page in the UCSC Genome Browser.