Kindling hypothesis of depression
The kindling hypothesis of depression posits that each period of depression in someone with major depressive disorder (MDD) causes neurological changes that predispose the person to future episodes. While the first episode of depression is often triggered by major life events, future episodes are less likely to be tied to circumstantial factors.[1] There is some evidence to support the kindling hypothesis.[2]
A 2022 review in Cureus focused on similarities between MDD and fibromyalgia and argues for a role of kindling in both disorders.[3]
References[edit]
- ^ Monroe, Scott M.; Harkness, Kate L. (2005). "Life Stress, the "Kindling" Hypothesis, and the Recurrence of Depression: Considerations From a Life Stress Perspective". Psychological Review. 112 (2): 417–445. doi:10.1037/0033-295X.112.2.417. PMID 15783292.
- ^ Rigoli, Francesco (17 November 2022). "When all glasses look half empty: a computational model of reference dependent evaluation to explain depression" (PDF). Journal of Cognitive Psychology. 34 (8): 1022–1031. doi:10.1080/20445911.2022.2107650. S2CID 251481438.
- ^ Yepez, Daniela; Grandes, Xavier A; Talanki Manjunatha, Ramya; Habib, Salma; Sangaraju, Sai Lahari (2022). "Fibromyalgia and Depression: A Literature Review of Their Shared Aspects". Cureus. 14 (5): e24909. doi:10.7759/cureus.24909. ISSN 2168-8184. PMC 9187156. PMID 35698706.