Not including its demonstration flight, Cygnus has been launched five times, with one, Cygnus CRS Orb-3, suffering a launch failure. Although designed to be launched by Orbital ATK's Antares rocket from Mid-Atlantic Regional Spaceport, damage to the launch pad caused by the Orb-3 failure led to two Cygnus missions being moved to Atlas V rockets launched from Cape Canaveral Air Force Station.
Cygnus was renewed for the second round of the Commercial Resupply Services in 2016.