English: Enterovirus replication cycle. The Enterovirus replication cycle is initiated by binding of the virus to the receptor and internalization into the cell. Subsequently, the viral RNA genome is released from the virion and translated into a single polyprotein which is then processed by the viral proteases to release the viral proteins. Next, the nonstructural proteins mediate the replication of the RNA genome via a negative-stranded intermediate. This takes place on replication organelles that are formed as a result of a rearrangement of cellular membranes. Newly synthesized positive-stranded RNA molecules can then either enter another round of translation and replication (not depicted) or they can be packaged into the viral capsid proteins to form new infectious virus particles which are released upon cell lysis and through several non-lytic mechanisms.