File:Distribution of estrogen radioactivity after a subcutaneous injection of tritiated estradiol or estrone in aqueous solution in rats.png
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Summary
| Description |
English: Distribution of estrogen radioactivity (dpm/mg dry tissue or dpm/5 μL blood) in blood and tissues after a single subcutaneous injection of 0.10 μg [3H]6,7-estradiol or 0.11 μg [3H]6,7-estrone in aqueous solution in rats. Points are median values of 6 rats except liver which are mean values of 4 aliquots of dried pooled tissue.
Estrone has one-tenth of the estrogenic potency of estradiol in animals. With similar doses of tritiated estrone and tritiated estradiol, the radioactivity in liver and blood was essentially the same. However, uterine radioactivity was markedly lower with tritiated estrone, about one-tenth of that of tritiated estradiol at 2 hours. As such, in contrast to estradiol, estrone was minimally retained in estrogen target tissues. In addition, uterine radioactivity with tritiated estrone at 15 minutes was mainly estrone, but at 2 hours radioactivity was almost all estradiol. Uterine tissue did not show the capacity to convert estrone into estradiol. As such, conversion of estrone into estradiol elsewhere appeared to be responsible for the uterine estrogenicity of estrone, and the one-tenth potency of estrone relative to estradiol is readily understandable. Source of the values:
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| Date | |
| Source | Own work |
| Author | Medgirl131 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 23:41, 8 June 2020 | | 2,228 × 1,364 (359 KB) | Vanished user 0x8cSXE0x6 | Uploaded own work with UploadWizard |
