Sperm-associated antigen 8

SPAG8
Identifiers
Aliases	SPAG8, BS-84, CILD28, CT142, HSD-1, SMP1, SPAG3, hSMP-1, sperm associated antigen 8
External IDs	OMIM: 605731 MGI: 3056295 HomoloGene: 8250 GeneCards: SPAG8
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 35,808,045 bp End 35,812,272 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 43,651,335 bp End 43,653,594 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube bronchial epithelial cell anterior pituitary left uterine tube right lobe of thyroid gland right lung thoracic diaphragm caudate nucleus left lobe of thyroid gland canal of the cervix Top expressed in spermatid spermatocyte seminiferous tubule otolith organ utricle olfactory epithelium right lung lobe neural tube proximal tubule left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function microtubule binding Cellular component acrosomal vesicle membrane cytoplasmic vesicle cytoskeleton cytoplasm nucleus spindle Biological process single fertilization cell differentiation spermatogenesis cell cycle biological process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26206 433700 Ensembl ENSG00000137098 ENSMUSG00000066196 UniProt Q99932 Q3V0Q6 RefSeq (mRNA) NM_001039592 NM_012436 NM_172312 NM_001007463 NM_001290462 RefSeq (protein) NP_001034681 NP_758516 NP_001353689 NP_001007464 NP_001277391 Location (UCSC) Chr 9: 35.81 – 35.81 Mb Chr 4: 43.65 – 43.65 Mb PubMed search
Wikidata
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Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Further reading

• Diekman AB, Herr JC (1997). "Sperm antigens and their use in the development of an immunocontraceptive". Am. J. Reprod. Immunol. 37 (1): 111–7. doi:10.1111/j.1600-0897.1997.tb00199.x. PMID 9138444. S2CID 39710127.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kuang Y, Yan YC, Gao AW, et al. (2001). "Immune responses in rats following oral immunization with attenuated Salmonella typhimurium expressing human sperm antigen". Arch. Androl. 45 (3): 169–80. doi:10.1080/01485010050193940. PMID 11111865. S2CID 218990195.
• Zhang XD, Miao SY, Wang LF, et al. (2001). "Human sperm membrane protein (hSMP-1): a developmental testis-specific component during germ cell differentiation". Arch. Androl. 45 (3): 239–46. doi:10.1080/01485010050194020. PMID 11111873. S2CID 218988933.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tang X, Zhang J, Cai Y, et al. (2004). "Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre". J. Mol. Med. 82 (6): 383–8. doi:10.1007/s00109-004-0535-2. PMID 15014887. S2CID 21455758.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cheng GY, Shi JL, Wang M, et al. (2007). "Inhibition of mouse acrosome reaction and sperm-zona pellucida binding by anti-human sperm membrane protein 1 antibody". Asian J. Androl. 9 (1): 23–9. doi:10.1111/j.1745-7262.2007.00247.x. PMID 17187156.