DescriptionNutritional Epigenetics Model for Autism and ADHD.png
English: Ultra-processed foods contain food colors, vegetable oils, refined sugars such as high fructose corn syrup (HFCS) and organophosphate (OP) and other pesticide residues. Consumption of ultra-processed foods leads to inorganic mercury (Hg) and lead (Pb) exposures and dietary deficits in important fatty acids (e.g. DHA, EPA) and micro-nutrients such as selenium (Se). Dietary consumption of HFCS and food colors, yellow #5 and yellow #6, leads to mineral imbalances such as zinc (Zn) and/or calcium (Ca) losses and copper (Cu) gain. Inadequate zinc stores and copper gain can disrupt metallothionein (MT) gene function and this results in the bio-accumulation of heavy metals in the blood stream which creates oxidative stress and changes in DNA methylation patterns that may impact child health and learning across generations. Inadequate calcium stores can lead to the bio-accumulation of Pb in the bloodstream and inhibit paraoxonase-1 (PON-1) gene function which is needed to detoxify the neurotoxic OP residues in the food supply. Without adequate PON1 gene activity, dietary exposures to OP pesticide residues result in oxidative stress and changes in DNA methylation patterns that impact child health and learning across generations.
Dufault et al. (2024). Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit hyperactivity disorder. World Journal of Psychiatry. 14(1): 159-178
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