File:Ivermectin mechanism of action 3RHW.png
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Summary
| Description |
English: Schematic diagram of the mechanism of action of ivermectin on the invertebrate glutamate-gated chloride channel receptor (GluClR), a pentameric ligand-gated ion channel. Ivermectin (IVM) interacts with a binding pocket formed by the transmembrane domains of adjacent GluClR subunits, "locking" the receptor in an activated (open) conformation that allows unrestricted passage of chloride (Cl−) ions into the cell. The plasma membrane is represented as a blue–pink gradient.
Français : Représentation schématique du mécanisme d'action de l'ivermectine sur le récepteur du "canal chlorure glutamate-dépendant" chez les invertébrés (GluClR ; un canal ionique pentamérique ligand-dépendant). L'ivermectine (IVM) interagit avec une poche de liaison formée par les domaines transmembranaires des sous-unités GluClR adjacentes, "bloquant" le récepteur dans une conformation activée (ouverte) permettant le passage sans restriction des ions chlorure (Cl-) dans la cellule. La membrane plasmique est représentée par un gradient bleu-rose.
Created using DS Studio Visualizer, PyMol (http://pymol.org), Inkscape, and GIMP. |
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| Date | |||
| Source | Own work, after PDB 3RHW. | ||
| Author | Fvasconcellos (talk · contribs) | ||
| Permission (Reusing this file) |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:47, 29 November 2020 | | 3,250 × 2,900 (2.57 MB) | Fvasconcellos | {{Information |Description=Schematic diagram of the mechanism of action of {{w|ivermectin}} on the invertebrate glutamate-gated chloride channel receptor (GluClR), a pentameric ligand-gated ion channel. Ivermectin (IVM) interacts with a binding pocket formed by the transmembrane domains of adjacent GluClR subunits, "locking" the receptor in an activated (open) conformation that allows unrestricted passage of chloride (Cl<sup>−</sup>) ions into the cell. The plasma membrane is represented as a... |
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