File:Interpretation of the cutoff effect in the frame of lipid hypothesis of anesthetic mechanism.png
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Summary
| Description |
English: A) Short hydrocarbon chains are relatively rigid in terms of conformational enthropy and are close to alkanol hydroxyl group (“buoy”) tethered to the interface. This makes short chain alkanols efficient mediators that redistribute lateral stress from membrane interior to its interface. B) This ability decreases in the row of n-alkanols since longer chains are more flexible and are not so tightly tethered to the hydroxyl group. C) Polyhydroxyalkanes 1,6,11,16-hexadecanetetraol and 2,7,12,17-octadecanetetraol exhibit significant anesthetic potency as was predicted by cutoff effect because the length of the hydrocarbon chain between hydroxyl groups is smaller than the cutoff. |
| Date | |
| Source | Own work |
| Author | Akuznetsova |
| Permission (Reusing this file) |
public domain |
This picture was made based on information obtained from J. Med. Chem., 2005, 48 (12), pp 4172–4176
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I, the copyright holder of this work, release this work into the public domain. This applies worldwide. In some countries this may not be legally possible; if so: I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:14, 21 April 2009 | | 1,450 × 628 (51 KB) | Akuznetsova | {{Information |Description={{en|1=A) Short hydrocarbon chains are relatively rigid in terms of conformational enthropy and are close to alkanol hydroxyl group (“buoy”) tethered to the interface. This makes short chain alkanols efficient mediators that |
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