ADCY4

ADCY4
Identifiers
Aliases	ADCY4, AC4, adenylate cyclase 4
External IDs	OMIM: 600292 MGI: 99674 HomoloGene: 23149 GeneCards: ADCY4
Gene location (Human) Chr. Chromosome 14 (human) Band 14q12 Start 24,318,349 bp End 24,335,093 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C3 Start 56,006,514 bp End 56,021,552 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in subcutaneous adipose tissue left uterine tube right lung left ventricle myometrium right lobe of thyroid gland canal of the cervix upper lobe of left lung spleen gastric mucosa Top expressed in external carotid artery internal carotid artery right lung right lung lobe left lung left lung lobe yolk sac carotid body soleus muscle heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding protein binding lyase activity phosphorus-oxygen lyase activity ATP binding guanylate cyclase activity protein kinase C binding adenylate cyclase activity Cellular component cytoplasm integral component of membrane membrane plasma membrane intracellular anatomical structure dendrite guanylate cyclase complex, soluble integral component of plasma membrane Biological process intracellular signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus cyclic nucleotide biosynthetic process renal water homeostasis cAMP biosynthetic process cGMP biosynthetic process signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196883 104110 Ensembl ENSG00000129467 ENSG00000284814 ENSMUSG00000022220 UniProt Q8NFM4 Q91WF3 RefSeq (mRNA) NM_139247 NM_001198568 NM_001198592 NM_080435 NM_001361604 RefSeq (protein) NP_001185497 NP_001185521 NP_640340 NP_536683 NP_001348533 Location (UCSC) Chr 14: 24.32 – 24.34 Mb Chr 14: 56.01 – 56.02 Mb PubMed search
Wikidata
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Adenylyl cyclase type 4 is an enzyme that in humans is encoded by the ADCY4 gene.

Function

This gene encodes a member of the family of adenylyl cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylyl cyclase 4, along with adenylyl cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylyl cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.

External links

• Human ADCY4 genome location and ADCY4 gene details page in the UCSC Genome Browser.

Further reading

• Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Hum. Genet. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689. S2CID 40521157.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566. S2CID 7620262.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185. S2CID 22105709.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Wong ST, Trinh K, Hacker B, et al. (2000). "Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice". Neuron. 27 (3): 487–97. doi:10.1016/S0896-6273(00)00060-X. PMID 11055432.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jcem.86.9.7837. PMID 11549699.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609. S2CID 36697419.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.