ADCY3

ADCY3
Identifiers
Aliases	ADCY3, AC3, AC-III, adenylate cyclase 3, BMIQ19
External IDs	OMIM: 600291 MGI: 99675 HomoloGene: 2978 GeneCards: ADCY3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,920,237 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,263,525 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sural nerve; ; left uterine tube; ; canal of the cervix; ; stromal cell of endometrium; ; gastric mucosa; ; subcutaneous adipose tissue; ; anterior pituitary; ; right lobe of thyroid gland; ; upper lobe of left lung;
	Top expressed in
	olfactory epithelium; ; brown adipose tissue; ; subiculum; ; submandibular gland; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; suprachiasmatic nucleus; ; superior frontal gyrus; ; medial vestibular nucleus; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; calmodulin binding; lyase activity; phosphorus-oxygen lyase activity; ATP binding; adenylate cyclase activity; guanylate cyclase activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; cell projection; membrane; plasma membrane; integral component of plasma membrane; cilium; guanylate cyclase complex, soluble;
Biological process	cAMP biosynthetic process; activation of protein kinase A activity; intracellular signal transduction; response to stimulus; cellular response to glucagon stimulus; cyclic nucleotide biosynthetic process; sensory perception of smell; renal water homeostasis; signal transduction; activation of adenylate cyclase activity; cGMP biosynthetic process; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; single fertilization; acrosome reaction; olfactory learning; flagellated sperm motility; cellular response to forskolin; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	109
	104111
	ENSG00000138031
	ENSMUSG00000020654
	O60266
	Q8VHH7
NM_004036; NM_001320613; NM_001377128; NM_001377129; NM_001377130;
	NM_001377131; NM_001377132
	NM_001159536; NM_001159537; NM_138305
NP_001307542; NP_004027; NP_001364057; NP_001364058; NP_001364059;
	NP_001364060; NP_001364061
	NP_001153008; NP_001153009; NP_612178
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.^[5]^[6]

Function[edit]

This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP).^[6]

The ADCY3 subtype likely mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138031 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020654 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang B, He B, Abdel-Halim SM, Tibell A, Brendel MD, Bretzel RG, Efendic S, Hillert J (Jan 1999). "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets". Biochemical and Biophysical Research Communications. 254 (3): 548–551. doi:10.1006/bbrc.1998.9983. PMID 9920776.
^ ^a ^b "Entrez Gene: ADCY3 adenylate cyclase 3".
^ "Gene Cards: ADCY3 Gene". Retrieved 2012-12-30.

External links[edit]

Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser.

Further reading[edit]

Gaudin C, Homcy CJ, Ishikawa Y (Nov 1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689. S2CID 40521157.
Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (Jul 1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Human Genetics. 94 (1): 69–73. doi:10.1007/BF02272844. PMID 8034296. S2CID 6473135.
Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cooper DM, Tabakoff B (Apr 1993). "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line". Biochemical and Biophysical Research Communications. 192 (1): 311–318. doi:10.1006/bbrc.1993.1415. PMID 8476432.
Wei J, Wayman G, Storm DR (Sep 1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo". The Journal of Biological Chemistry. 271 (39): 24231–24235. doi:10.1074/jbc.271.39.24231. PMID 8798667.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.
Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR (Sep 1998). "Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals". Neuron. 21 (3): 495–504. doi:10.1016/S0896-6273(00)80561-9. PMID 9768837. S2CID 9860137.
Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv. 437 (4): 538–546. doi:10.1007/s004240050815. PMID 10089566. S2CID 7620262.
Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–636. doi:10.1097/00002030-200004140-00001. PMID 10807185. S2CID 22105709.
Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975–982. doi:10.1067/mai.2000.105315. PMID 10808179.
Vanvooren V, Allgeier A, Cosson E, Van Sande J, Defer N, Pirlot M, Hanoune J, Dumont JE (Dec 2000). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid". Molecular and Cellular Endocrinology. 170 (1–2): 185–196. doi:10.1016/S0303-7207(00)00322-1. PMID 11162902. S2CID 20099267.
Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. S2CID 24053412.
Côté M, Guillon G, Payet MD, Gallo-Payet N (Sep 2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism. 86 (9): 4495–4503. doi:10.1210/jcem.86.9.7837. PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology. 76 (7): 3179–3188. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
Kobayakawa K, Hayashi R, Morita K, Miyamichi K, Oka Y, Tsuboi A, Sakano H (Jul 2002). "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons". The Journal of Neuroscience. 22 (14): 5931–7. doi:10.1523/JNEUROSCI.22-14-05931.2002. PMC 6757947. PMID 12122055.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609. S2CID 36697419.
Katsel PL, Tagliente TM, Schwarz TE, Craddock-Royal BD, Patel ND, Maayani S (Feb 2003). "Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets". Platelets. 14 (1): 21–33. doi:10.1080/0953710021000062905. PMID 12623444. S2CID 7194996.
Celano M, Arturi F, Presta I, Bruno R, Scarpelli D, Calvagno MG, Cristofaro C, Bulotta S, Giannasio P, Sacco R, Filetti S, Russo D (May 2003). "Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules". Molecular and Cellular Endocrinology. 203 (1–2): 129–135. doi:10.1016/S0303-7207(03)00086-8. PMID 12782409. S2CID 24573371.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138031 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020654 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9920776-5] Yang B, He B, Abdel-Halim SM, Tibell A, Brendel MD, Bretzel RG, Efendic S, Hillert J (Jan 1999). "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets". Biochemical and Biophysical Research Communications. 254 (3): 548–551. doi:10.1006/bbrc.1998.9983. PMID 9920776.

[entrez-6] "Entrez Gene: ADCY3 adenylate cyclase 3".

[genecards-7] "Gene Cards: ADCY3 Gene". Retrieved 2012-12-30.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)